This course explores analytical approaches to understanding multi-country neighborhoods defined by physical proximity. It examines and compares patterns of boundary setting, conflict, and cooperation at the regional level. We debate the question of whether we are in transit to a world of regions where geography and regionality are foundational to the whole international system. The majority of sessions delve in depth into the experience of one particular region, for example Europe, post-Soviet Eurasia, Southeast Asia, the Middle East, or sub-Saharan Africa.